Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds
作者： Sandrine S. Ferreira , Amélia M. Silva , Fernando M. Nunes
DOI: 10.1016/J.INDCROP.2017.10.009
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摘要: Abstract Citrus reticulata Blanco industrial use worldwide generates millions of tons by-products, mainly peels, with negative environmental impact. The main purpose this work was to compare the extraction efficiency water and 70% ethanol, for recovering C. peel phenolic compounds. A simple solid phase method used obtaining enriched extracts. There were no significant differences in two solvents used. components hesperidin, naringin, tangeritin, rutin, that accounted nearly 86% total phenolics extracted. Solid allowed a 4.5-fold enrichment antioxidant activity anti-proliferative extracts found be dose-dependent but also dependent on cell line. after 48 h exposure presented an IC50 174.5 ± 5.8 μg/mL (BT-474), 391.9 ± 15 μg/mL (Caco-2) >500.00 μg/mL (HepG2). These results show peels are cheap abundant source potentially bioactive
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