The role of chemotherapy in the treatment of low-grade glioma. A review of the literature.

摘要: Low-grade gliomas (LGG) are a group of uncommon neuroglial tumors the central nervous system. They characterized by grade I or II according to WHO classification. Grade non-invasive and amenable surgical resection with curative intent. Diffuse infiltrating LGG (WHO II) highly variable prognosis. Curative can only rarely be achieved progression is transformation into high-grade glioma III-IV). There limited evidence-based treatment recommendations for management progressive because lack data from prospective randomized trials. Most often radiotherapy offered patients symptomatic and/or disease. Three trials have failed demonstrate survival improvement either early versus delayed radiation higher dose radiation. The potential role chemotherapy has been addressed in phase PCVchemotherapy regimen associated considerable toxicity that limits its applicability. results temozolomide (TMZ) more promising. Patients chemosensitive as predicted heterozygotic loss chromosomal arms 1p 19q methylation promoter MGMTgene genome cells respond TMZ. Radiotherapy will compared first line two III studies planned brain tumor European Organization Research Treatment Cancer (BTG-EORTC) Radiation Therapy Oncology Group (RTOG).