Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence

摘要: Background: Near-perfect levels of HIV medication adherence are necessary for treatment to be successful. However, many patients continue report nonadherence treatment.Purpose: This study examines the relationship between symptoms and evaluates beliefs about medications negative mood states as potential mediators this relationship.Methods: These relationships were tested with structural equation modeling using a 15-month longitudinal design. The ethnically diverse convenience sample included 325 HIV-infected men who have sex women prescribed Highly Active Antiretroviral Therapy (HAART).Results: Results showed that greater number associated poorer adherence, was partially mediated by increases in concerns HAART. Contrary expectations, not directly related adherence. In final model, HAART general distrust each predicted Necessity level educational attainment better model accounted approximately 24% variance adherence.Conclusions: results suggest Horne’s (1) necessity-concerns framework can successfully applied identify important predictors over time. findings relevance developing interventions improve among patients.