Developing recombinant and synthetic vaccines for the treatment of melanoma.

摘要: To develop new vaccines for the treatment of patients with cancer, target antigens presented on tumor cell surfaces have been cloned. Many these are non-mutated differentiation and expressed by virtually all melanomas, making them attractive components a widely efficacious melanoma vaccine. These also melanocytes, however, likely to be subject immune tolerance. A central challenge immunologists has thus breaking tolerance cancer antigens. We review recent clinical trials using experimental vaccines, including evidence that therapeutic can induce objective responses in metastatic malignant melanoma. focus foundations approaches animal models designed test novel report what predict future development cancer.