Trastuzumab-induced cardiotoxicity in elderly women with HER-2-positive breast cancer: a meta-analysis of real-world data
作者： Henry WC Leung , Agnes LF Chan
DOI: 10.1517/14740338.2015.1089231
关键词:
摘要: Background: We conducted a meta-analysis to assess the overall risk of cardiac toxicity associated with trastuzumab treatment in elderly breast cancer patients. Methods: searched databases from PubMed, EMBASE and Cochrane Central Registry Controlled Trials identify relevant studies. Statistical analyses were calculate incidence rate, hazard ratio (HR) 95% CIs using fixed effects model. Results: A total 116,342 360 patients five cohort studies two randomized clinical trials (RCTs) included for analysis. The pooled incidences symptomatic congestive heart failure (CHF) CHF/HF/CM 6.4% (95% CI 4.1% – 9.4) 16.4% 16.19% 16.61) median age 67.5 years RCTs (60 75), 71 (66 80+), 74.5 (65 89), 75 81+) 79.5 99) studies, respectively. Trastuzumab was significantly correlated an increased defined tox...
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