Array-based Comparative Genomic Hybridization in the Analysis of Genomic Alterations in Human Disease

摘要: Besides their utilization in gene expression studies, the concept of using microarrays has been explored study other molecular genetic aspects human disease. This includes use arrays for detection gains and losses genomic DNA. Fluctuations DNA sequence copy number with concomitant microscopic or cryptic chromosomal aberrations are becoming increasingly correlated phenotypic abnormalities. Characteristic isolated abnormalities occur a variety inherited syndromes, amplification, deletion, both is common alteration occurring cancer cells. The development many neoplasms follows defined series histopathologic stages, process that involves multiple changes such as translocations, deletions, duplications, alterations changes. Importantly, often involve areas harboring oncogenes tumor suppression genes play an important role cell cycle control, affects growth.