The Impact of EGFR Mutation Status on Outcomes in Patients With Resected Stage I Non-Small Cell Lung Cancers

作者: Benjamin Izar , Lecia Sequist , Mihan Lee , Alona Muzikansky , Rebecca Heist

DOI: 10.1016/J.ATHORACSUR.2013.05.091

关键词:

摘要: … 62 harbored tumors with EGFR mutations and 245 had wild-type EGFR. Tumors in patients with EGFR mutations were associated with a significantly lower recurrence rate (9.7% versus …

参考文章(21)
Wei-An Song, Nai-Kang Zhou, Wei Wang, Xiang-Yang Chu, Chao-Yang Liang, Xiao-Dong Tian, Jun-Tang Guo, Xi Liu, Yang Liu, Wei-Min Dai, Survival Benefit of Neoadjuvant Chemotherapy in Non-small Cell Lung Cancer: An Updated Meta-Analysis of 13 Randomized Control Trials Journal of Thoracic Oncology. ,vol. 5, pp. 510- 516 ,(2010) , 10.1097/JTO.0B013E3181CD3345
Sandra P. D’Angelo, Yelena Y. Janjigian, Nicholas Ahye, Gregory J. Riely, Jamie E. Chaft, Camelia S. Sima, Ronglai Shen, Junting Zheng, Joseph Dycoco, Mark G. Kris, Maureen F. Zakowski, Marc Ladanyi, Valerie Rusch, Christopher G. Azzoli, Distinct Clinical Course of EGFR -Mutant Resected Lung Cancers: Results of Testing of 1118 Surgical Specimens and Effects of Adjuvant Gefitinib and Erlotinib Journal of Thoracic Oncology. ,vol. 7, pp. 1815- 1822 ,(2012) , 10.1097/JTO.0B013E31826BB7B2
Young Tae Kim, Yong Won Seong, Yoo Jin Jung, Yoon Kyung Jeon, In Kyu Park, Chang Hyun Kang, Joo Hyun Kim, The presence of mutations in epidermal growth factor receptor gene is not a prognostic factor for long-term outcome after surgical resection of non-small-cell lung cancer. Journal of Thoracic Oncology. ,vol. 8, pp. 171- 178 ,(2013) , 10.1097/JTO.0B013E318277A3BB
Jenifer L. Marks, Stephen Broderick, Qin Zhou, Dhananjay Chitale, Allan R. Li, Maureen F. Zakowski, Mark G. Kris, Valerie W. Rusch, Christopher G. Azzoli, Venkatraman E. Seshan, Marc Ladanyi, William Pao, Prognostic and Therapeutic Implications of EGFR and KRAS Mutations in Resected Lung Adenocarcinoma Journal of Thoracic Oncology. ,vol. 3, pp. 111- 116 ,(2008) , 10.1097/JTO.0B013E318160C607
William Pao, Vincent A Miller, Katerina A Politi, Gregory J Riely, Romel Somwar, Maureen F Zakowski, Mark G Kris, Harold Varmus, Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain PLoS Medicine. ,vol. 2, pp. e73- ,(2005) , 10.1371/JOURNAL.PMED.0020073
Hui-Ping Liu, Hong-Dar Isaac Wu, John Wen-Cheng Chang, Yi-Cheng Wu, Hsin-Yi Yang, Ya-Ting Chen, Wen-You Hsieh, Ying-Tsong Chen, Yi-Rong Chen, Shiu-Feng Huang, Prognostic Implications of Epidermal Growth Factor Receptor and KRAS Gene Mutations and Epidermal Growth Factor Receptor Gene Copy Numbers in Patients with Surgically Resectable Non-small Cell Lung Cancer in Taiwan Journal of Thoracic Oncology. ,vol. 5, pp. 1175- 1184 ,(2010) , 10.1097/JTO.0B013E3181E2F4D6
Ken-Hong Lim, Ming-Jer Huang, Hung-Chang Liu, Hsu-Tah Kuo, Chin-Yuan Tzen, Ruey-Kuen Hsieh, Lack of prognostic value of EGFR mutations in primary resected non-small cell lung cancer Medical Oncology. ,vol. 24, pp. 388- 393 ,(2007) , 10.1007/S12032-007-0018-8
Yelena Y Janjigian, Bernard J Park, Maureen F Zakowski, Marc Ladanyi, William Pao, Sandra P D'Angelo, Mark G Kris, Ronglai Shen, Junting Zheng, Christopher G Azzoli, None, Impact on Disease-Free Survival of Adjuvant Erlotinib or Gefitinib in Patients with Resected Lung Adenocarcinomas that Harbor EGFR Mutations Journal of Thoracic Oncology. ,vol. 6, pp. 569- 575 ,(2011) , 10.1097/JTO.0B013E318202BFFE
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
Masashi Adachi, Kazuhiro Yanagihara, Yosuke Otake, Hiromi Wada, Fumihiro Tanaka, Makoto Sonobe, Masatsugu Nakagawa, Kazumasa Takenaka, Hiromichi Katakura, Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer. Journal of Surgical Oncology. ,vol. 95, pp. 63- 69 ,(2007) , 10.1002/JSO.20547