Pathophysiological Studies of Overactive Bladder and Bladder Motor Dysfunction in a Rat Model of Metabolic Syndrome
作者： Wei-Chia Lee , Yao-Chi Chuang , Po-Hui Chiang , Chiang-Ting Chien , Hong-Jeng Yu
DOI: 10.1016/J.JURO.2011.03.037
关键词:
摘要: Purpose: We studied bladder motor dysfunction and searched for markers of neurogenic myogenic alterations among fructose fed rats with or without abnormal voiding behavior.Materials Methods: Female Wistar were a rich diet (60%) normal 6 months. Based on cystometry behavior the divided into 3 groups, including group detrusor function micturition frequency, overactivity increased frequency acontractile frequency. Denuded tissues obtained to assess in vitro contractility, postsynaptic receptors, smoothelin, nitrosative products intrinsic pathway apoptosis.Results: Fructose had obvious alterations, expression dysregulation smoothelin decreased Bcl-2 wit...
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