The activity of lung afferent nerves during tracheal occlusion.

摘要: We have recorded the activity of 72 pulmonary stretch receptors isolated from 34 rabbits and 19 3 cats both with animal breathing through an open tracheal tube against a closed airway. In first breath during airway occlusion done at FRC 36.1% showed increase firing inspiratory effort compared expiratory pause (inspiratory modulation). 47.2% no change in frequency between two phases respiratory 16.7% increased their phase (expiratory However, average modulation occluded was only 7% that observed control 2% so overall discharge ascending vagus nerves hardly varied inspiration to expiration. During some normally silent became active while others activity. This departure amounts 6% breathing. We interpret behaviour as due re-distribution air within lung or deformation airway. We also studied 8 irritant receptors: 6 2 cats. All were diminished when occluded. When re-opened these greatly augmented last observation could explain after period occlusion.