Response of pulmonary stretch receptors to shifts of functional residual capacity

摘要: Abstract The response of slowly adapting pulmonary stretch receptors (PSRs) to sustained elevations functional residual capacity (FRC) was investigated in spontaneous breathing anesthetized cats. A subatmospheric pressure produced around the thorax and abdomen increase FRC by approximately one tidal volume (V T ) for up 60 min. During eupneic PSR frequency (f closely related changes transpulmonary (P TP ), bu occasionally hysteresis observed f - P relationship. Elevation caused most phasic PSRs discharge continously a few breaths before returning pattern. shift there were increases mean , peak firing threshold which throughout period elevated FRC. that normally showed discharges at similarly increased their rates. For all y-intercept ( = 0) relationship decreased but sensitivity as defined Δf /ΔP not changed until exceeded 30 Thereafter, tended decline. There results suggest undergo some modification parameters during prolonged elevation