Nonuniform biosynthesis of multiple hemoglobins in the adult rat and guinea pig.
作者： E Weiser , C K Yeh , W Lin , A Mazur
DOI: 10.1016/S0021-9258(17)33114-9
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摘要: Separation of adult rat bone marrow cells by the method thin layer countercurrent distribution permits analyses 59Fe-tagged erythroid for various multiple hemoglobins and assignment such to at different stages their development. Of six red cell hemoglobins, hemoglobin 5 is synthesized most actively in earliest whereas 4 (the major cell) latest cells, e.g. reticulocyte. Experimental evidence also indicates that maturation accompanied a decreased rate synthesis 5. The contain two 7 8, which are absent cell. Similar studies with guinea pig confirm nonuniform biosynthesis its suggest phenomenon may be general one among mammalian hemoglobins.
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