Semisynthesis of new tetrahydrofuranic alkyl ester and furano-pyrone derivatives as inhibitors of the mitochondrial complex I
作者： Eva Peris , Adrien Cavé , Ernesto Estornell , M.Carmen Zafra-Polo , Bruno Figadère
DOI: 10.1016/S0040-4020(01)01234-0
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摘要: Abstract Methoxymethylation of altholactone ( 1 ) led to the corresponding O -methoxymethyl derivative 3 in addition unexpected 6,7-dihydro-7-methoxy analogue 4 ), and two original tetrahydrofuranic (THF) alkyl esters 5 , 6 ). Moreover, when we accomplished a new method for preparation furano-pyrone goniofupyrone 7 through 7-hydroxylation acid medium, minor compound 8 with an identical skeleton that compounds was identified. Careful examination published spectral data reported styryl-lactones heptolide reveals those structures possess also THF ester skeleton. The revision confirmed by chemical correlation. All derivatives assayed proved be specific inhibitors mitochondrial complex I.
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