Alterations in event-related potentials (ERPs) of MPTP-treated monkeys.
作者： Andrew Glover , M.Felice Ghilardi , Ivan Bodis-Wollner , Marco Onofrj
DOI: 10.1016/0168-5597(88)90050-0
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摘要: Abstract Using an auditory ‘oddball’ paradigm and classical conditioning, we have studied evoked potentials (AEPs) P300-like in monkeys pre- post-MPTP treatment. Free-field acoustic stimuli were 500 Hz 4000 tones, which designated as the ‘frequent’ ‘rare’ conditions, respectively. The reinforced with mild somatosensory electrical stimulation. During first few weeks following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) administration, all gradually developed a parkinsonian syndrome, partially, but not completely improved within 30–40 days 2 animals. amplitudes of AEP initially significantly decreased, progressively returned to pretreatment magnitudes partially recovered. abolished animals; however, later P300 spontaneously re-emerged same monkeys. Latencies both these signals unaffected by MPTP. Acute administration dopamine precursor during phase neurotoxicity temporarily depressed amplitudes, did restore absent potentials. relevance results for Parkinson's disease is discussed.
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