Too much to handle - how gaining chromosomes destabilizes the genome.
作者： Verena Passerini , Zuzana Storchová
DOI: 10.1080/15384101.2016.1231285
关键词:
摘要: Most eukaryotic organisms are diploid, with 2 chromosome sets in their nuclei. Whole chromosomal aneuploidy, a deviation from multiples of the haploid number, arises segregation errors and often has detrimental consequences for cells. In humans, numerical aneuploidy severely impairs embryonic development rare survivors develop disorders characterized by multiple pathologies. Moreover, as many 75 % malignant tumors display aneuploidy. Although exact contribution to tumorigenesis remains unclear, previous studies have suggested that may affect maintenance genome integrity. We found human cells extra chromosomes showed phenotypes suggestive replication defects, phenomenon which we went on characterize being due aneuploidy-driven downregulation factors, particular replicative helicase MCM2-7. Thus, missegregation even single can further promote genomic instability thereby contribute tumor development. this review will examine possible causes factors discuss aneuploid
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