Nano and microcarriers to improve stem cell behaviour for neuroregenerative medicine strategies: Application to Huntington's disease.
作者： Emilie M. André , Catherine Passirani , Begona Seijo , Alejandro Sanchez , Claudia N. Montero-Menei
DOI: 10.1016/J.BIOMATERIALS.2015.12.008
关键词:
摘要: The potential treatments for neurodegenerative disorders will be revolutionized by the transplantation of stem cells or neuronal progenitors derived from these cells. It is however crucial to better monitor their proliferation, improve survival and differentiation hence ameliorate engraftment after transplantation. To direct cell fate, a delicate control gene expression through RNA interference (RNAi) emerging as safe epigenetic approach. development novel biomaterials (nano microcarriers) capable delivering proteins, nucleic acids cells, open possibility regulate fate while achieving neuroprotection neurorepair could applied Huntington's disease. This review first provides an overview therapy disorder Within that context, integrative discussion follows behaviour RNAi delivered different nanocarriers in vitro prior Finally, combined vivo strategies using regulation are reported.
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