Social reinstatement: a rat model of peer-induced relapse.

摘要: An important factor that can lead to drug relapse is re-associate with drug-using social peers, but there little literature on the effect of peers in animal models. The current study used a dual-compartment operant conditioning apparatus allowed adult male rats respond for cocaine presence conspecific. In experiment 1, were trained self-administer peer was separated by wire screen partition and then as reinstatement cue following period extinction. next experiments, alternating sessions one saline different using either single-active lever procedure (experiment 2) or double-active 3). Following extinction responding absence re-exposure cocaine- saline-associated seeking determined. This tested both single- procedures. present throughout self-administration able reinstate experiments 2 3, reinstated cocaine-associated (S+), not (S−). discrimination occurred when procedure. These results indicate be discriminative stimulus signal availability re-introduction previously paired seeking, confirming clinical reports affiliation among abstinent users an determinant relapse.