The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli.

摘要: Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams all classes. Especially, carbapenem antibiotics are more efficiency than other beta-lactam antibiotics. The enzymes found most often Enterobacteriaceae. Recently, these have isolates Pseudomonas aeruginosa Acinetobacter spp. observations blaKPC genes isolated different species countries indicate that common but unknown ancestor may mobilized areas or blaKPC-carrying bacteria passively by many vectors. emergence Gram-negative is worrisome because be associated with non-beta-lactam Treatment infections caused KPC-producing extremely difficult their multidrug resistance, which results high mortality rates. Therapeutic options treat multiresistant producing KPC-carbapenemases could used polymyxin B tigecycline.