Endocrinology: bone as a target tissue for hormonal regulation.

摘要: Publisher Summary Bone is a dynamic tissue in mice that changes continually during development, achieves adult skeletal size and density long after pubertal maturation, continues to undergo renewal throughout adulthood. There are broad differences parameters among inbred strains of mice, without doubt there as much variation any parameter observed within the human population. The regulation murine bone—environmental intrinsic—is remarkably similar humans thus experimental analyses have widely focused on in-vivo in-vitro rodent model systems. Thus, this chapter addresses field endocrinology from perspective skeleton illustrates hormonal actions fundamental tissue. When formation accentuated, increased mass results, conversely when resorption predominates, loss results. balance between these two processes termed “coupling” research into determining how or what agent responsible for coordinating processes. Finally, large number induced mutations such as, gene knockouts, knockins, transgenic overexpression models, available facilitating investigations by scientist interested biology bone.