Structure and regulation of the growth hormone secretagogue receptor.

摘要: Synthetic growth hormone secretagogues (GHS) stimulate release through binding to a recently cloned specific secretagogue receptor (GHS-R). Ghrelin, the endogenous ligand of this receptor, is part new endocrine pathway controlling GH secretion. However, major physiological function ghrelin/GHS-R system may be related control energy homeostasis. The GHS-R belongs family G-protein coupled receptors. Two different variants type 1a and 1b have been described which differ in their carboxyl-terminal amino acids. Both types are encoded by single gene approximately 4.3 kb length processing. promoter region human was characterized. Analysis lead insights into secretion additional roles ghrelin. This review will summarize data regarding structure protein encoded, reports investigating expression various tissues, studies underlying transcriptional mechanisms.