Drugs in Lactation

摘要: One impediment to breastfeeding is the lack of information on use many drugs during lactation, especially newer ones. The principles drug passage into breastmilk are well established, but have often not been optimally applied prospectively. Commonly used preclinical rodent models for determining excretion milk very unreliable because marked differences in composition and transporters compared those humans. Measurement concentrations humans remains gold standard, computer modeling promising. New FDA labeling requirements present an opportunity apply development place conventional animal testing breastmilk, which should improve medications nursing mothers.