Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome.
作者： William C. Earnshaw , Barbara R. Migeon
DOI: 10.1007/BF00329812
关键词:
摘要: We developed an aqueous spreading procedure that permits simultaneous analysis of human chromosomes by Q-banding and indirect immunofluorescence. Using this methodology anticentromere antibodies from autoimmune patient we compared the active inactive centromeres isodicentric X chromosome. show a family structurally related centromere proteins (CENP-A, CENP-B, CENP-C) is detectable only at centromere. These antigens therefore may be regarded both as morphological functional markers for centromeres.
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