Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages.

作者: Miodrag Belosevic , Carol A. Nacy

DOI: 10.1016/0008-8749(90)90055-V

关键词:

摘要: Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability resist infection amastigotes of Leishmania major. In this cooperative interaction cytokines, can be replaced any several mAb directed against beta chain receptor, but not by antibodies a number other cell receptors or antigens. Thus, receptor act as agonists in induction biologic activity macrophages, nonproliferating type, respond signals transmitted through receptor.

参考文章(20)
E M Shevach, T R Malek, R J Robb, G Ortega, The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. Journal of Immunology. ,vol. 133, pp. 1970- 1975 ,(1984)
T A Waldmann, W C Greene, C K Goldman, L Casabo, W Holter, D L Nelson, Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes. Journal of Immunology. ,vol. 138, pp. 2917- 2922 ,(1987)
E M Shevach, E Tschachler, G Stingl, W Knapp, G Steiner, W Holter, K Wolff, M Tani, T R Malek, Interleukin 2 receptors on cultured murine epidermal Langerhans cells. Journal of Immunology. ,vol. 137, pp. 155- 159 ,(1986)
C A Nacy, E J Leonard, M S Meltzer, D J Wyler, Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/HeN mouse macrophages. Journal of Immunology. ,vol. 127, pp. 2381- 2386 ,(1981)
W Knapp, H Stockinger, R Grunow, W Holter, Recombinant interferon-gamma induces interleukin 2 receptors on human peripheral blood monocytes. Journal of Immunology. ,vol. 136, pp. 2171- 2175 ,(1986)
Carol A. Nacy, Monte S. Meltzer, Macrophages in Resistance to Rickettsial Infection: Macrophage Activation in Vitro for Killing of Rickettsia Tsutsugamushi Journal of Immunology. ,vol. 123, pp. 2544- 2549 ,(1979)
J H Kehri, M Dukovich, G Whalen, P Katz, A S Fauci, W C Greene, Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. Journal of Clinical Investigation. ,vol. 81, pp. 200- 205 ,(1988) , 10.1172/JCI113295