Bioactive, degradable and multi-functional three-dimensional membranous scaffolds of bioglass and alginate composites for tissue regenerative applications
作者： P. Bargavi , R. Ramya , S. Chitra , S. Vijayakumari , R. Riju Chandran
DOI: 10.1039/D0BM00714E
关键词:
摘要: With a worldwide increase in the aged populace and associated geriatric diseases, there is an enormous need for regeneration of degenerated organ systems. For this purpose, bioactive glass particulate (nBG) integrated alginate (Alg) composite membrane scaffolds were fabricated by sol-gel assisted freeze-drying method validated their multifunctional utility regenerative medicine. The presence combeite highly crystalline structure nBG Alg amorphous broad peaks confirmed. Repetitive from acids along with stretching confirmed chemical interactions composites. Swelling ability, porosity, vitro degradation biomineralization analysed up to 7 days. results indicated that reduced swelling enhanced apatite formation. Hemocompatibility hemostatic properties on also systematically investigated. Additionally, significant cyto-compatibility proliferation noted culture KB3-1. Further 3-D co-cultures HDF cells KB3-1 exhibited spheroid formation Alg, nBG/Alg nBG-Zr/Alg profound dynamism required establish organoids interest. Thus, indicate these 3D hydrogel membranes could offer infinite possibilities field medicine, notably as extracellular matrix (ECM) supporting bone, intra-vascularization, neo-tissue formation, such cartilage ligaments.
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