Factors associated to aspirin failure for secondary stroke prevention

摘要: Background It is not settled whether aspirin (ASA) failure may be predicted in stroke and transient ischemic attack (TIA) patients. The risk of ASA by analyzing the epidemiological traits patients with or TIA. Patients methods We evaluated retrospectively 695 TIA admitted to Downtown Barcelona Stroke Registry, including 54 who recurred while on 125-500 mg/day (group failure), 178 showed a good clinical response same dose for at least one year follow-up sensitive). Vascular factors, subtypes, radiological findings were compared both groups. Results On multivariate analysis was independently correlated history myocardial infarction, nonvalvular atrial fibrillation hypercholesterolemia. A trend toward age older than 65 also failure. contrary, periventricular lucencies protector factor. severity onset unrelated intake onset. Conclusions Males females years, coronary heart disease fibrillation, serum cholesterol level > 240 mg/dl, CT scan showing no evidence small vessel are, respectively, characteristics most frequently encountered suffer an despite preventive treatment ASA. Moreover, this does reduce initial long-term severity.