Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.

摘要: Bilateral aspiration of the dorsal hippocampus produced a disrupttion blocking rabbit's nictitating membrane response in Kamin's two-stage paradigm (Experiment 1) but had no effect on formation Pavlovian conditioned inhibitor 2). The results Experiment 1 indicated that normal animals and those with cortical lesions given conditioning to light-plus-tone stimulus (CS) gave responses (CRs) both light tone during nonreinforced presentations each (test phase). If, however, compound was preceded by acquisition, only elicited CR testing; is, observed. In rabbits hippocampal lesions, CRs were testing whether or not acquisition. data from 2 showed could discriminate as well between (CS+) plus (CS-). addition, when inhibitory subsequently paired unconditioned retardation testing, all three lesion conditions acquired at same rate. Thus, it appears do disrupt inhibition. these experiments taken support for view is responsible "tuning out" stimuli have adaptive value organism.