Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

摘要: The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for phenomenon are largely unknown. Here we report oxytocin—a hormone best known its role in lactation, parturition and social behaviours—is required proper tissue regeneration homeostasis, plasma levels oxytocin decline Inhibition signalling animals reduces regeneration, whereas administration rapidly improves enhancing aged stem cell activation/proliferation through activation the MAPK/ERK pathway. We further show genetic lack does not cause a developmental defect but instead leads premature sarcopenia. Considering is an FDA-approved drug, work reveals potential novel safe way combat or prevent ageing. age-related mice circulation. Elabd et al.identify hormone, oxytocin, as mediator effect, showing age regeneration.