Expression of microglial markers in the human CNS after closed head injury.

作者: S. Engel , H. D. Wehner , R. Meyermann

DOI: 10.1007/978-3-7091-9465-2_16

关键词:

摘要: The loss of neurons after severe closed head injury is not only a consequence the primary impact but also secondary damage mechanisms. Among cell population central nervous system microglia surely candidate to influence mechanisms by releasing cytotoxic cytokines [1]. About microglial reaction in traumatic brain (TBI), however, no data are available. In contrast experiments using stab wound coverings CNS TBI still intact.

参考文章(28)
Margaret M. Esiri, Christine S. Morris, Immunocytochemical study of macrophages and microglial cells and extracellular matrix components in human CNS disease Journal of the Neurological Sciences. ,vol. 101, pp. 59- 72 ,(1991) , 10.1016/0022-510X(91)90018-3
Stephen M. Gentleman, Michael J. Nash, Christopher J. Sweeting, David I. Graham, Gareth W. Roberts, β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury Neuroscience Letters. ,vol. 160, pp. 139- 144 ,(1993) , 10.1016/0304-3940(93)90398-5
A. SASAKI, Y. NAKAZATO, The identity of cells expressing MHC class II antigens in normal and pathological human brain. Neuropathology and Applied Neurobiology. ,vol. 18, pp. 13- 26 ,(1992) , 10.1111/J.1365-2990.1992.TB00761.X
L.J. Lawson, V.H. Perry, P. Dri, S. Gordon, Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain Neuroscience. ,vol. 39, pp. 151- 170 ,(1990) , 10.1016/0306-4522(90)90229-W
Jochen Gehrmann, Richard B. Banati, Georg W. Kreutzberg, Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules Journal of Neuroimmunology. ,vol. 48, pp. 189- 198 ,(1993) , 10.1016/0165-5728(93)90191-Z
Manuel B. Graeber, Wolfgang J. Stre'rt, Microglia: Immune Network in the CNS Brain Pathology. ,vol. 1, pp. 2- 5 ,(1990) , 10.1111/J.1750-3639.1990.TB00630.X
M Sean Grady, Mark R. Mclaughlin, Carole W. Christman, Alex B. Valadka, Corinne L. Fligner, John T. Povlishock, The Use of Antibodies Targeted Against the Neurofilament Subunits for the Detection of Diffuse Axonal Injury in Humans Journal of Neuropathology and Experimental Neurology. ,vol. 52, pp. 143- 152 ,(1993) , 10.1097/00005072-199303000-00007
C A Colton, C Abel, J Patchett, J Keri, J Yao, Lectin staining of cultured CNS microglia. Journal of Histochemistry and Cytochemistry. ,vol. 40, pp. 505- 512 ,(1992) , 10.1177/40.4.1372634