Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude.

摘要: Although microglia are considered to be a sensitive sensor for pathological processes in the central nervous system, there only few studies about distribution and density of normal human brain. Therefore, study local microglial cells was conducted by investigating 20 brains with no clinical neurological symptoms or diseases neuropathological alterations. Microglial were visualized immunolabeling proteins which known expressed either constitutively facultatively, such as CD68, major histocompatibility complex class II (MHC-II), leukocyte common antigen (LCA), chemotactic factor (LCF), macrophage inhibitory factor-related protein (MRP) 8, MRP14, CD4 allograft-inflammatory factor-1 (AIF-1). MHC-II AIF-1 showed highest densities significant regional differences ranging from 0.5% 16.6% all brain parenchyma significantly more white than gray matter. LCF LCA similar pattern described above, but lower percentages cells. not found parenchyma. We conclude that define main cell population, whereas subpopulation The negligible vascular expression MRP8 MRP14. Information can serve reference evaluation responses.