Interleukin-16 Polymorphism Is Associated with an Increased Risk of Glioma
作者： Qi-Sheng Luo , Jun-Li Wang , Yuan-Yang Deng , Hua-Dong Huang , Huang-De Fu
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摘要: Objective: Previous studies have shown that interleukin (IL)-16 is overexpressed in human and rat gliomas. Potential links between IL-16 polymorphisms glioma risk are currently unclear. The aim of this study was to investigate the association risk. Methods: We examined gene (i.e., rs4778889, rs11556218, rs4072111) 216 patients with 275 controls a Chinese population. Genotypes were determined using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay. Odds ratios (OR) their corresponding 95% confidence intervals (CI) used evaluate effect on Results: rs11556218TG genotype associated an increased compared TT (OR=1.76; CI, 1.22–2.54; p=0.002). Similarly, rs11556218G allele T (OR=1.41; 1.06–1.87; p=0.017). How...
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