Experimental stroke in gerbils: correlation of clinical, pathological and electroencephalographic findings and protein synthesis.

摘要: Cerebral ischemia was produced in gerbils by ligation of the right common carotid artery and resulting clinical manifestations pathological alterations, along with electroencephalographic findings, were followed from 30 minutes to 24 hours. Protein synthesis evaluated brain slices vitro subsequent cellular subcellular fractionations. One group animals developed signs cerebral stroke very rapidly often died within 12 In these infarction diffuse side a few hours post-operatively there persistent suppression recordings. Amino acid incorporation into protein fractions decreased 50% opposite at further declined less than 10% 8 10 Another survived spite severe neurological manifestations, about 15% control The observed both neuronal neurologlial indicating similar vulnerability elements toward as shown anoxia past. It emphasized that correlation biochemical data is important extract meaningful information investigations this model.