The Role of Adjuvant Therapy with Bisphosphonates in Cancer

摘要: An understanding of the pathophysiology bone metastases requires a knowledge normal and abnormal remodeling. This is helpful in mechanisms action active agents such as bisphosphonates. When malignant cells infiltrate spaces, balance formation resorption disrupted: remodeling turnover become abnormal. The consequent ‘vicious cycle’ plays central role progressive destruction progression metastases. cycle breast cancer beginning to be understood involves secretion by substances parathyroid hormone related protein (PTHrP) which leads an increase focal generalized resulting release breakdown products transforming growth factor beta turn stimulates further cells. Study intricacies this has thrown some light on potential opportunities for therapy However, physiological pain are poorly understood. Clinical aspects cancer, prostate myeloma, together with what known about their individual discussed review. Biochemical markers now available study early research suggests that skeletal events patients disease well treatment these may correlate levels serum urine turnover.