SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells.
作者： Kang Min Lee , Kangwook Lee , Youn Kyung Choi , Yu-Jeong Choi , Hye-Sook Seo
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摘要: Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development common therapeutic agents treat cancer, there are several limitations their use owing side effects and drug resistance, which induce recurrence. The anticancer new herbal mixture SH003 (comprising Astragalus membranaceus, Angelica gigas Trichosanthes kirilowii Maximowicz) have been examined various types cancer. Thus, present study hypothesized be an effective treatment for cervical inhibited growth HeLa cells, whereas it did not affect rat intestinal epithelial cells. addition, increased expression apoptosis‑related proteins promoted apoptotic cell death also led G1 phase arrest Furthermore, induced production reactive oxygen species (ROS); however, ROS appear related SH003‑mediated apoptosis. Results from indicated SH003‑induced inhibition mediated through extrinsic apoptosis, suggested potential
sci-hub.se 参考文章(53)
Peter, Storz, Reactive oxygen species in tumor progression Frontiers in Bioscience. ,vol. 10, pp. 1881- 1896 ,(2005) , 10.2741/1667
Gun-Hee Kim, Eun-Jeong Choi, Antioxidant and anticancer activity of Artemisia princeps var. orientalis extract in HepG2 and Hep3B hepatocellular carcinoma cells. Chinese Journal of Cancer Research. ,vol. 25, pp. 536- 543 ,(2013) , 10.3978/J.ISSN.1000-9604.2013.10.02
Jing Lv, Zhimin Zhao, Yuan Chen, Qinglan Wang, Yanyan Tao, Li Yang, Tai-Ping Fan, Chenghai Liu, The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evidence-based Complementary and Alternative Medicine. ,vol. 2012, pp. 284963- 284963 ,(2012) , 10.1155/2012/284963
Dunyaporn Trachootham, Jerome Alexandre, Peng Huang, Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature Reviews Drug Discovery. ,vol. 8, pp. 579- 591 ,(2009) , 10.1038/NRD2803
William C.S. Cho, Kwok N. Leung, In Vitro and in Vivo Anti-Tumor Effects of Astragalus Membranaceus Cancer Letters. ,vol. 252, pp. 43- 54 ,(2007) , 10.1016/J.CANLET.2006.12.001
Hui-Man Cheng, Chia-Cheng Li, Calvin Yu-Chian Chen, Hsin-Yi Lo, Wen-Yu Cheng, Chang-Hsien Lee, Shi-Zhe Yang, Shih-Lu Wu, Chien-Yun Hsiang, Tin-Yun Ho, Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation Journal of Ethnopharmacology. ,vol. 132, pp. 429- 437 ,(2010) , 10.1016/J.JEP.2010.08.022
Magdalena L. Circu, Tak Yee Aw, Reactive oxygen species, cellular redox systems, and apoptosis Free Radical Biology and Medicine. ,vol. 48, pp. 749- 762 ,(2010) , 10.1016/J.FREERADBIOMED.2009.12.022
Richard J. Youle, Andreas Strasser, The BCL-2 protein family: opposing activities that mediate cell death Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 47- 59 ,(2008) , 10.1038/NRM2308
Meng Li, Xiang Li, Ji-Cheng Li, Possible mechanisms of trichosanthin-induced apoptosis of tumor cells. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 293, pp. 986- 992 ,(2010) , 10.1002/AR.21142
Haiying Luo, Feifei Wang, Yan Bai, Tianfeng Chen, Wenjie Zheng, Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest. Colloids and Surfaces B: Biointerfaces. ,vol. 94, pp. 304- 308 ,(2012) , 10.1016/J.COLSURFB.2012.02.006