Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches.

摘要: Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that turned either on or off, which dramatically alters the metabolism and overall activity cell, with complex machinery enzymes involved glycolipids not being an exception. The aberrant glycosylation surface majority cells, associated increasing evidence about functional role these molecules a number cellular physiological pathways, has received considerable attention as convenient immunotherapeutic target for treatment. This resulted development substantial passive active immunotherapies, have shown promising results clinical trials. More recently, antibodies to also emerged attractive tool targeted delivery cytotoxic agents, thereby providing rationale future therapeutic interventions review first summarizes molecular bases metabolic pathway expression glycolipids, both normal tumor paying particular sialosylated (gangliosides). current strategies battle against key players then described.