Embryonic diapause and its regulation.

摘要: Embryonic diapause, a condition of temporary suspension development the mammalian embryo, occurs due to suppression cell proliferation at blastocyst stage. It is an evolutionary strategy ensure survival neonates. Obligate diapause in every gestation some species, while facultative ensues others, associated with metabolic stress, usually lactation. The onset, maintenance and escape from are regulated by cascades environmental, hypophyseal, ovarian uterine mechanisms that vary among species between obligate condition. In best-known models, rodents, environment maintains embryo estrogens, combination growth factors, reinitiate development. Mitotic arrest G0 or G1 phase cycle, may be expression specific cycle inhibitor. Regulation non- models provide clues orthologous genes whose regulate reprise context.