Impact of Antihypertensive Agents on Central Systolic Blood Pressure and Augmentation Index: A Meta-Analysis

摘要: Background New evidence suggests that central systolic blood pressure (cSBP) and augmentation index (AI) are superior predictors of adverse cardiovascular outcomes compared to peripheral BP (pSBP). We performed a meta-analysis assessing the impact antihypertensives on cSBP AI. Methods PubMed, Cochrane Library, CINAHL were searched until September 2014 identify eligible articles. A DerSimonian Laird random-effects model was used calculate weighted mean difference (WMD) its 95% confidence interval (CI). Fifty-two 58 studies incorporating 4,381 3,716 unique subjects included for AI analysis, respectively. Results Overall, reduced pSBP more than (WMD 2.52 mm Hg, CI 1.35 3.69; I (2) = 21.9%). β-Blockers (BBs) posed significantly greater reduction in as 5.19 3.21 7.18). α-Blockers, angiotensin converting enzyme inhibitors, II receptor blockers, calcium channel diuretics, renin-angiotensin aldosterone system inhibitors nicorandil similar manner. The overall from baseline 3.09% (95% 2.28 3.90; 84.5%). significant seen with BBs, α-blockers (ABs), nicorandil, moxonidine nonsignificantly. Conclusions BBs not beneficial other reducing