Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension.

摘要: BACKGROUND Central blood pressure (BP) is pathophysiologically more important than peripheral BP for the pathogenesis of cardiovascular disease. Arterial stiffness also a good predictor morbidity and mortality. The effects benidipine, unique dual L-/T-type calcium channel blocker, on central have not been reported. This study aimed to compare effect benidipine losartan arterial in mild moderate essential hypertensives. METHODS 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group was designed as non-inferiority study. eligible patients (n = 200) were randomly assigned receive 101) or 99). Radial artery applanation tonometry pulse wave analysis used measure BP, velocity (PWV) augmentation index (AIx). We measured metabolic inflammatory markers. RESULTS After decreased significantly from baseline by (16.8 ± 14.0/10.5 9.2) mmHg (1 0.133 kPa) (systolic/diastolic BP; P < 0.001) (18.9 14.7/12.1 10.2) (P respectively. Both groups lowered AIx 0.05), but there no significant differences between two groups. mean aortic, brachial femoral PWV did change both after 24-week treatment. There changes biomarkers each group. CONCLUSION Benidipine effective lowering improving stiffness.