Sexual Dimorphism in Hepatic, Adipose Tissue, and Peripheral Tissue Insulin Sensitivity in Obese Humans.

摘要: Glucose and lipid metabolism differ between men women, women tend to have better whole-body or muscle insulin sensitivity. This may be explained, in part, by differences sex hormones adipose tissue distribution. Few studies investigated gender hepatic, sensitivity severely obese women. In this study, we aimed determine the glucose using tissue-specific measurements of Insulin was compared age body mass index (BMI)-matched a two-step euglycemic hyperinsulinemic clamp with infusion [6,6-2H2]glucose. Basal endogenous production liver, peripheral tissues were assessed. Liver fat content assessed proton magnetic resonance spectroscopy subset included subjects. We 46 (age, 48±2 vs 46±2 years, p=0.591; BMI, 41±1 kg/m2, p=0.832). There no difference basal (14.4±1.0 15.3±0.5 µmol•kg fat-free mass-1•min-1, p=0.410), (insulin-mediated suppression free fatty acids, 71.6±3.6 76.1±2.6%, p=0.314) (insulin-stimulated rate disappearance glucose, 26.2±2.1 22.7±1.7 µmol•kg-1•min-1, p=0.211). Obese characterized lower hepatic production, 61.7±4.1 72.8±2.5% resp., p=0.028). Finally, these observations could not explained liver (men 16.5±3.1 16.0±2.5%, p=0.913, n=27). conclude that but comparable tissue, similarly Hepatic resistance contribute higher prevalence diabetes men. Further insight into mechanisms underlying reveal novel targets for prevention and/or therapy.