Associations among histological characteristics and patient outcomes in colorectal carcinoma with a mucinous component.
作者： Raul S Gonzalez , Justin M M Cates , Kay Washington
DOI: 10.1111/HIS.13748
关键词:
摘要: Aims Colorectal carcinoma (CRC) often has a mucinous component, with more than 50% mucin by volume defining the subtype of CRC. The prognostic impact phenotype remains unclear. Methods and results We evaluated 224 CRC at least 5% component (herein 'mCRC') for patient sex, age, race outcome; tumour size, location, stage microsatellite instability (MSI) status; percentage glands producing mucin; composed whether tumoral epithelium floated in pools; budding; signet ring cells (SRCs); peritumoural inflammation (PI). related these features to disease-specific survival compared outcomes 499 stage-matched, conventional colorectal adenocarcinomas. Factors predicting worse prognosis mCRC on univariable analysis included non-MSI-high status (P = 0.0008), SRC 0.0017) lack PI 0.0034). No parameters were independently associated outcome after adjusting multivariate analysis. did not affect prognosis, including recommended cut-off subtyping mCRC. Disease-specific adenocarcinomas similar accounting stage. Conclusions Stage-matched mCRCs have outcomes, no significance morphological subtyping. Histological characteristics mCRC, comprised mucin, predictive outcome.
sci-hub.se 参考文章(36)
Ulrich Nitsche, Helmut Friess, Ayman Agha, Martin Angele, Renate Eckel, Wolf Heitland, Karl-Walter Jauch, Detlef Krenz, Natascha C. Nüssler, Horst-Günter Rau, Reinhard Ruppert, Gabriele Schubert-Fritschle, Dirk Wilhelm, Jens Werner, Jutta Engel, Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort Journal of Cancer Research and Clinical Oncology. ,vol. 142, pp. 2357- 2366 ,(2016) , 10.1007/S00432-016-2224-2
Charly Liddell, Laure Droy-Dupré, Sylvie Métairie, Fabrice Airaud, Christelle Volteau, Stéphane Bezieau, Christian L Laboisse, Jean-François Mosnier, Mapping clinicopathological entities within colorectal mucinous adenocarcinomas: a hierarchical clustering approach. Modern Pathology. ,vol. 30, pp. 1177- 1189 ,(2017) , 10.1038/MODPATHOL.2017.18
Alessandro Lugli, Richard Kirsch, Yoichi Ajioka, Fred Bosman, Gieri Cathomas, Heather Dawson, Hala El Zimaity, Jean-François Fléjou, Tine Plato Hansen, Arndt Hartmann, Sanjay Kakar, Cord Langner, Iris Nagtegaal, Giacomo Puppa, Robert Riddell, Ari Ristimäki, Kieran Sheahan, Thomas Smyrk, Kenichi Sugihara, Benoît Terris, Hideki Ueno, Michael Vieth, Inti Zlobec, Phil Quirke, Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Modern Pathology. ,vol. 30, pp. 1299- 1311 ,(2017) , 10.1038/MODPATHOL.2017.46
Rondell P. Graham, Robert A. Vierkant, Lori S. Tillmans, Alice H. Wang, Peter W. Laird, Daniel J. Weisenberger, Charles F. Lynch, Amy J. French, Susan L. Slager, Yassaman Raissian, Joaquin J. Garcia, Sarah E. Kerr, Hee Eun Lee, Stephen N. Thibodeau, James R. Cerhan, Paul J. Limburg, Thomas C. Smyrk, Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort. The American Journal of Surgical Pathology. ,vol. 39, pp. 1340- 1346 ,(2015) , 10.1097/PAS.0000000000000504
Niek Hugen, Gina Brown, Robert Glynne-Jones, Johannes H. W. de Wilt, Iris D. Nagtegaal, Advances in the care of patients with mucinous colorectal cancer Nature Reviews Clinical Oncology. ,vol. 13, pp. 361- 369 ,(2016) , 10.1038/NRCLINONC.2015.140
Yoshihiro Kazama, Toshiaki Watanabe, Takamitsu Kanazawa, Tomohiro Tada, Junichiro Tanaka, Hirokazu Nagawa, Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability: a study matched for T classification and tumor location. Cancer. ,vol. 103, pp. 2023- 2029 ,(2005) , 10.1002/CNCR.21022
Hisato Kawakami, Aziz Zaanan, Frank A. Sinicrope, Microsatellite instability testing and its role in the management of colorectal cancer. Current Treatment Options in Oncology. ,vol. 16, pp. 30- 30 ,(2015) , 10.1007/S11864-015-0348-2
Niek Hugen, Michiel Simons, Altuna Halilović, Rachel S van der Post, Anna J Bogers, Monica AJ Marijnissen-van Zanten, Johannes HW de Wilt, Iris D Nagtegaal, The molecular background of mucinous carcinoma beyond MUC2 The Journal of Pathology: Clinical Research. ,vol. 1, pp. 3- 17 ,(2015) , 10.1002/CJP2.1
James D. Lutterbaugh, William M. Grady, Ashwani Rajput, Sanford D. Markowitz, Detection of Aberrantly Methylated hMLH1 Promoter DNA in the Serum of Patients with Microsatellite Unstable Colon Cancer Cancer Research. ,vol. 61, pp. 900- 902 ,(2001)
Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596