From Obesity to Diabetes

摘要: The frequent development of Type 2 diabetes in the obese suggests a relationship between obesity and diabetes. This study presents evidence for continuum form to via glucose intolerance hyperinsulinemic defect which seems be at origin this resides increase lipid oxidation already present early stages obesity. It reflects increased utilisation fatty acids energy purpose obese, expenses glucose. In non-diabetic subjects, insulin resistance can demonstrated by inhibition storage during euglycemic, hyperinsulinemic, clamp. is not observed oral tolerance test (OGTT), as it compensated hyperinsulinemia hyperglycemia tolerance. Glucose appears with augmented oxidation. decreased utilization causes slowdown glycogen stores leads, consequence, synthase its product, glycogen. Diabetes when glycemia insulinemia does compensate any more storage. rise basal simultaneously fall corresponds transition mobilization together phosphorylase are such diabetic patient that tend remain full inhibited negative feedback. retrograde on activity brings up incapacity store leads glycemia. Finally, evolution decrease secretion hepatic production through gluconeogenesis capacity Therapeutic implications discussed review.