Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene
作者： Stephan W. Morris , A. Thomas Look
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摘要: The present invention is based on the identification and sequence determination of a novel gene, ALK, which fused to gene encoding nucleophosmin (NPM) in translocations t(2;5) lymphoma cells. Based homologies other proteins, amino acid polypeptide encoded by ALK (Anaplastic Lymphoma Kinase) membrane-spanning protein tyrosine kinase (PTK)/receptor. Antibodies PTK/receptor methods utilizing such antibodies are described, as using isolate ligands for PTK/receptor.
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