Method for detecting fusion gene

作者: Kazuya Omi

DOI:

关键词:

摘要: Disclosed is a means which enables simple and rapid detection of the presence any fusion genes including even unknown genes. The method for measuring gene(s) according to present invention applied sample separated from living body, comprises: expressions 5′-region 3′-region one component may be in wherein said upstream downstream point genes; comparing expression with 3′-region. gene measured e.g. between ALK another gene.

参考文章(25)
Laurence Lamant, Nicole Dastugue, Karen Pulford, Georges Delsol, Bernard Mariamé, A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. Blood. ,vol. 93, pp. 3088- 3095 ,(1999) , 10.1182/BLOOD.V93.9.3088
Sadao Kuromitsu, Hiroyuki Mano, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani, EML4-ALK fusion gene ,(2007)
Ruth H. Palmer, Emma Vernersson, Caroline Grabbe, Bengt Hallberg, Anaplastic lymphoma kinase: signalling in development and disease Biochemical Journal. ,vol. 420, pp. 345- 361 ,(2009) , 10.1042/BJ20090387
Christoph M Ahlers, William Figg, II, ETS-TMPRSS2 fusion gene products in prostate cancer. Cancer Biology & Therapy. ,vol. 5, pp. 254- 255 ,(2006) , 10.4161/CBT.5.3.2603
Young Lim Choi, Kengo Takeuchi, Manabu Soda, Kentaro Inamura, Yuki Togashi, Satoko Hatano, Munehiro Enomoto, Toru Hamada, Hidenori Haruta, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Toshihide Ueno, Shuji Takada, Yoshihiro Yamashita, Yukihiko Sugiyama, Yuichi Ishikawa, Hiroyuki Mano, Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer Cancer Research. ,vol. 68, pp. 4971- 4976 ,(2008) , 10.1158/0008-5472.CAN-07-6158
J Gabert, E Beillard, V H J van der Velden, W Bi, D Grimwade, N Pallisgaard, G Barbany, G Cazzaniga, J M Cayuela, H Cavé, F Pane, J L E Aerts, D De Micheli, X Thirion, V Pradel, M González, S Viehmann, M Malec, G Saglio, J J M van Dongen, Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program Leukemia. ,vol. 17, pp. 2318- 2357 ,(2003) , 10.1038/SJ.LEU.2403135
S. Morris, M. Kirstein, M. Valentine, K. Dittmer, D. Shapiro, D. Saltman, A. Look, Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma Science. ,vol. 263, pp. 1281- 1284 ,(1994) , 10.1126/SCIENCE.8122112
Manabu Soda, Young Lim Choi, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Shunpei Ishikawa, Shin-ichiro Fujiwara, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Masashi Bando, Shoji Ohno, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiro Niki, Yasunori Sohara, Yukihiko Sugiyama, Hiroyuki Mano, None, Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer Nature. ,vol. 448, pp. 561- 566 ,(2007) , 10.1038/NATURE05945