Glypicans shunt the Wingless signal between local signalling and further transport.

摘要: The two glypicans Dally and Dally-like have been implicated in modulating the activity of Wingless, a member Wnt family secreted glycoprotein. So far, lack null mutants has prevented rigorous assessment their roles. We created small deletion loci. Our analysis single double mutant embryos suggests that both participate normal Wingless function, although lacking maternal zygotic genes are still capable transducing signal from overexpressed Wingless. Genetic dally-like wing imaginal discs leads us to model whereby, at surface any given cell epithelium, captures but instead presenting it signalling receptors expressed this cell, passes on neighbouring cells, either for paracrine or further transport. In absence dally-like, short-range is increased expense long-range (reported by expression target gene distalless) while reverse caused overexpression. Thus, act as gatekeeper, ensuring sharing among cells along dorsoventral axis. other glypican, Dally, could classical co-receptor.