Association between inherited monogenic liver disorders and chronic hepatitis C.

摘要: AIM: To determine the frequencies of mutations that cause inherited monogenic liver disorders in patients with chronic hepatitis C. METHODS: This study included 86 C (55 men, 31 women; mean age at diagnosis, 38.36 ± 14.52 years) who had undergone antiviral therapy comprising pegylated interferon and ribavirin. Viral load, biochemical parameter changes, biopsy morphological data were evaluated all patients. The control group comprised 271 unrelated individuals representing general population Latvia for mutation frequency calculations. most frequent [gene (mutation): ATP7B (H1069Q), HFE (C282Y, H63D), UGT1A1 (TA)7, SERPINA1 (PiZ)] detected by polymerase chain reaction (PCR), bidirectional PCR allele-specific amplification, restriction fragment length polymorphism analysis, sequencing. RESULTS: viral genotype was 80 genotypes 1, 2, 3 present 61 (76%), 7 (9%), 12 (15%) patients, respectively. Among 50 (58%) reached an early response 70 (81%) a sustained response. All 16 did not reach 1. Case-control analysis revealed statistically significant difference only H1069Q between controls (patients, 0.057; controls, 0.012; odds ratio, 5.514; 95%CI: 1.119-29.827, P = 0.022). However, associated treatment outcomes or indices. (TA) gene decreased ferritin levels (beta regression coefficient -295.7, 0.0087). CONCLUSION: Genetic diseases should be studied detail.