Progesterone for Maintenance Tocolytic Therapy After Threatened Preterm Labor: A Randomized Controlled Trial

摘要: Although patients in whom preterm labor is arrested are at an increased risk of recurrence, it not clear whether maintenance tocolytic treatment appropriate. In this randomized trial, the ability supplemental vaginal progesterone a daily dose 400 mg to prevent recurrences was assessed 70 women 24-34 weeks' gestation who presented with symptoms threatened and uterine activity arrested. Progesterone chosen for study because can maintain quiescent uterus has been widely used primary or secondary prevention delivery. Preterm defined as more than 6 contractions 30 minutes along cervical shortening dilation. Thirty-seven received while 33 were untreated. Baseline characteristics similar 2 groups. Latency delivery significantly longer progesterone-treated (36.1 versus 24.5 days). There also significant differences favoring therapy incidence respiratory distress syndrome (10.8% 36.4%); birth weight (3101 2609 gm); low (27% 51.5%). No group found respect recurrent labor, admission intensive care, neonatal sepsis. no cases necrotizing enterocolitis intraventricular hemorrhage, infants exhibited congenital malformations. addition, adverse effects observed treated progesterone. The use suppositories following successful tocolysis associated predelivery interval study, but did reduce frequency readmission labor.