Progesterone and Preterm Birth Prevention: Translating Clinical Trials Data into Clinical Practice

摘要: 0002-9378/free © 2012 Published by Mosby, Inc. OBJECTIVE: We sought to provide evidenc the prevention of preterm birth (PTB). METHODS: Relevant documents, in part PubMed (US National Library Medicine, 19 English, which evaluate effectiveness o gens evaluated were, particular, vaginal pr caproate. Additionally, Cochrane Library, through review above were utilized according population studied, with separa prior PTB, or short transvaginal ultrasound c factors. Consistent US Preventive Task F quality based on highest level evidence RESULTS AND RECOMMENDATIONS: S women singleton gestations, no PTB progesterone, either 90-mg gel 200-mg su perinatal morbidity and mortality, can be screening gestations without debate. CL gestatio mandated. Nonetheless, implementation s sonable, considered individua gleton 20-36 6/7 w 250 mg intramuscularly weekly, preferably st mended. In these if at 24 weeks, cervical cerclage may offer who have labor, premature rupture mem mend use progestogens