Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice.
作者： Su-jun Sun , Ying-ying Feng , Yan Zhang , Hai-yu Ji , Juan Yu
DOI: 10.3390/MOLECULES23010046
关键词:
摘要: Degeneration of immune organs like thymus and spleen has been discovered in tumor-bearing mice; which increases the difficulties on oncotherapy. More effective drugs target protection are expected to be researched. In this study; we aim analyze antitumor immunoregulatory activities seleno-β-lactoglobulin (Se-β-lg) S180 mice. Results indicated that Se-β-lg exhibited a remarkable inhibitory effect solid tumors with inhibition rate 48.38%; protected thymuses spleens S180-bearing addition, could also balance proportions CD4+ CD8+ T cells spleens; peripheral bloods; improve Levels IL-2; IFN-γ; TNF-α mice serums. β-lg showed weaker bioactivities while SeO2 stronger toxicity Therefore our results demonstrated possessed lower side effects had potential novel immunopotentiator agent.
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