Prevention of the Mutagenecity and Cytotoxicity of Oxidized Purine Nucleotides
作者： Yusaku Nakabeppu , Mehrdad Behmanesh , Hiroo Yamaguchi , Daisuke Yoshimura , Kunihiko Sakumi
DOI: 10.1007/978-0-387-72974-9_3
关键词:
摘要: Damage to nucleic acids is particularly hazardous because the genetic information in genomic DNA, such as nuclear and mitochondrial can be altered. accumulated cellular DNAs often initiates programmed cell death, well mutagenesis. The former may cause degenerative diseases, latter result neoplasia hereditary diseases. accumulation of oxidative damage DNA or RNA a incorporation oxidized nucleotides generated nucleotide pools, their direct oxidation. Recent progress studies sanitization addition repair, have revealed significance oxidation free unexpectedly large, comparison DNA.
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