Comparison of the effects of exercise with chondroitin sulfate on knee osteoarthritis in rabbits

摘要: The aim of the study is to compare effects exercise therapy with chondroitin sulfate (CS) in an experimental model osteoarthritis (OA). Twenty-one New Zealand rabbits were randomly divided into four groups: normal group (N group, n = 3); OA control (C n = 6); plus medication (CS and (E n = 6). Four weeks after modeling, subjected (artificial, 30 min/time, 4 times/week) or medicated CS (2% CS, 0.3 ml/time, once/week) for 4 weeks. Histopathological changes treated joints examined staining. X-ray scanning electron microscopy was used evaluate different therapies by examining surfaces joint spaces articular cartilage. RT-qPCR assess chondrogenic gene expression including Col2, Col10, mmp-13, il-1β, adamats-5, acan groups. Histology showed both treatment groups resulted cartilage that good condition, increased numbers chondrocytes, results therapeutic effect equivalent therapy, surface flat, layer thinning. All induced Col10 Col2 decreased adamats-5 compared upregulated E downregulated group. Furthermore, higher il-1β lower These indicate has a positive on it also supplies reference movement mode improve function.