Facile functionalization of Teriflunomide-loaded nanoliposomes with Chondroitin sulphate for the treatment of Rheumatoid arthritis
作者： Asiya Mahtab , Syed Arman Rabbani , Yub Raj Neupane , Shweta Pandey , Adil Ahmad
DOI: 10.1016/J.CARBPOL.2020.116926
关键词: In vivo 、 Toxicity 、 Rheumatoid arthritis 、 Pharmacology 、 Chemistry 、 Adjuvant 、 Teriflunomide 、 Biodistribution 、 Viability assay 、 Receptor
摘要: This research aims to coat Teriflunomide (TEF) loaded conventional nanoliposomes (CON-TEF-LIPO) with Chondroitin sulphate (CS) produce CS-TEF-LIPO for the effective treatment of Rheumatoid arthritis (RA). Both CON-TEF-LIPO and were produced, characterized evaluated their active targeting potential towards CD44 receptors. Cell cytotoxicity, cell viability intracellular uptake study on differentiated U937 MG-63 cells demonstrated Furthermore, in vivo pharmacodynamic, biochemical, radiological histopathological studies performed adjuvant induced arthritic (AIA) rat model showed a significant (P < 0.05) reduction inflammation paw group compared TEF groups. Moreover, liver toxicity revealed that no signs biodistribution accumulation synovial region rat. Taken together, results suggest could provide new insight an RA.
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