Protecting group-free method for synthesis of N-glycosyl carbamates and an assessment of the anomeric effect of nitrogen in the carbamate group.
作者： Rika Ochi , Nobuyoshi Saeki , Toshiya Masuda , Takahiro Minami , Yoshiyasu Ichikawa
DOI: 10.1016/J.CARRES.2021.108280
关键词:
摘要: Abstract The first protecting group-free synthesis of N-glycosyl carbamates has been developed through reaction D-glucose with n-butyl carbamate in acidic aqueous media. structures the N-glucosyl were unambiguously determined by comparison authentic samples, prepared using isocyanide method. With this protective method for hand, an anomeric pair N-xylopyranosyl and used to assess effect nitrogen group.
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